Title : Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002.

Pub. Date : 2017 Jan 15

PMID : 27832967






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Modelling of the mTOR1 kinetics showed that Rapamycin has an IC50 independent of ATP concentration and that it is a selective inhibitor of mTOR1 substrates S6K1 and 4EBP1: it retains 40% of mTOR1 activity relative to 4EBP1 phosphorylation and inhibits completely S6K1 activity. Sirolimus eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens
2 Modelling of the mTOR1 kinetics showed that Rapamycin has an IC50 independent of ATP concentration and that it is a selective inhibitor of mTOR1 substrates S6K1 and 4EBP1: it retains 40% of mTOR1 activity relative to 4EBP1 phosphorylation and inhibits completely S6K1 activity. Sirolimus eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens