Pub. Date : 2016 Nov 10
PMID : 27831559
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Decreased expression of microRNA-17 and microRNA-20b promotes breast cancer resistance to taxol therapy by upregulation of NCOA3. | Paclitaxel | microRNA 17 | Homo sapiens |
| 2 | By real-time PCR analysis, we found that miR-17 and miR-20b were significantly reduced in taxol-resistant breast cancer tissues and cells. | Paclitaxel | microRNA 17 | Homo sapiens |
| 3 | In addition, we provided some experimental evidences that miR-17 and miR-20b attenuated breast cancer resistance to taxol in vitro and in vivo models. | Paclitaxel | microRNA 17 | Homo sapiens |
| 4 | Together, our results indicated that loss of miR-17 and miR-20b enhanced breast cancer resistance to taxol by upregulating NCOA3 levels. | Paclitaxel | microRNA 17 | Homo sapiens |
| 5 | Our study suggested miR-17, miR-20b and NCOA3 may serve as some predictive biomarkers and potential therapeutic targets in taxol-resistant breast cancer treatment. | Paclitaxel | microRNA 17 | Homo sapiens |