Title : Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism.

Pub. Date : 2016 Nov 29

PMID : 27816967






2 Functional Relationships(s)
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Protein Name
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1 In sorafenib-resistant cells, ubenimex inhibited the Akt signaling pathway that regulates autophagy. Sorafenib AKT serine/threonine kinase 1 Homo sapiens
2 In summary, lipophagy participates in sorafenib-resistance of RCC, which could be reversed by interventions targeting the Akt pathway. Sorafenib AKT serine/threonine kinase 1 Homo sapiens