Pub. Date : 2016 Nov
PMID : 27812757
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3). | Dantrolene | solute carrier family 22 member 7 | Homo sapiens |
| 2 | Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3). | Dantrolene | solute carrier family 22 member 7 | Homo sapiens |
| 3 | SLC22A7 (OAT2) was less sensitive to dantrolene and 5-OH dantrolene with IC50 values of 15.6 +- 2.1 and 15.8 +- 3.2 muM, respectively. | Dantrolene | solute carrier family 22 member 7 | Homo sapiens |
| 4 | SLC22A7 (OAT2) was less sensitive to dantrolene and 5-OH dantrolene with IC50 values of 15.6 +- 2.1 and 15.8 +- 3.2 muM, respectively. | Dantrolene | solute carrier family 22 member 7 | Homo sapiens |
| 5 | If no other transporter markedly contributes to uptake or release of ES or cGMP, respectively, these data suggest that OAT3 and OAT2 may be involved in absorption, metabolism, and excretion of dantrolene and its metabolite 5-OH dantrolene. | Dantrolene | solute carrier family 22 member 7 | Homo sapiens |