Title : Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities.

Pub. Date : 2017 Feb

PMID : 27811010






1 Functional Relationships(s)
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1 Because single-agent MEK inhibitors have been limited as a first-line targeted therapy due to compensatory activation of other oncogenic signaling pathways, we combined MEK162 with the PI3K/Akt inhibitor buparlisib. NVP-BKM120 thymoma viral proto-oncogene 1 Mus musculus