Title : Potential role of IL-17-producing CD4/CD8 double negative αβ T cells in psoriatic skin inflammation in a TPA-induced STAT3C transgenic mouse model.

Pub. Date : 2017 Jan

PMID : 27810232






5 Functional Relationships(s)
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1 OBJECTIVE: To investigate which subsets of IL-17-producing cells are involved in psoriasis-like skin inflammation in a TPA (tumor promoter 12-O-tetradecanoylphorbol-13-acetate)-induced K14.Stat3C mouse model. Tetradecanoylphorbol Acetate keratin 14 Mus musculus
2 OBJECTIVE: To investigate which subsets of IL-17-producing cells are involved in psoriasis-like skin inflammation in a TPA (tumor promoter 12-O-tetradecanoylphorbol-13-acetate)-induced K14.Stat3C mouse model. Tetradecanoylphorbol Acetate keratin 14 Mus musculus
3 METHOD: Skin-infiltrating cells were isolated from inflamed lesions of TPA-treated K14.Stat3C transgenic mice, and analyzed for IL-17 producing cell subsets by flow cytometry. Tetradecanoylphorbol Acetate keratin 14 Mus musculus
4 RESULTS: We observed significantly increased numbers of IL-17-producing CD4+ T cells, CD8+ T cells and dermal gammadelta T cells in TPA-induced skin lesions of K14.Stat3C mice. Tetradecanoylphorbol Acetate keratin 14 Mus musculus
5 CONCLUSION: In TPA-induced lesional skin of K14.Stat3C mice, IL-17-producing CD4+ Th17 cells, CD8+ Tc17 cells, dermal gammadelta T cells and TCR- cells probably containing ILCs all participated in skin inflammation, which is similar to human clinical psoriatic features. Tetradecanoylphorbol Acetate keratin 14 Mus musculus