Pub. Date : 2017 Jan 24
PMID : 27791982
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ErbB2 inhibition by lapatinib promotes degradation of mutant p53 protein in cancer cells. | Lapatinib | tumor protein p53 | Homo sapiens |
| 2 | Here we report that pharmacological interception of this circuit by ErbB2 inhibitor lapatinib downregulates mutant p53 in vitro and in vivo. | Lapatinib | tumor protein p53 | Homo sapiens |
| 3 | We found that ErbB2 inhibition by lapatinib inhibits transcription factor HSF1, and its target Hsp90, followed by mutant p53 degradation in MDM2 dependent manner. | Lapatinib | tumor protein p53 | Homo sapiens |
| 4 | Thus, our data suggest that mutant p53 sensitizes cancer cells to lapatinib via two complementary mechanisms: mutant p53 mediated amplification of ErbB2 signaling, and simultaneous annihilation of both potent oncogenic drivers, ErbB2 and mutant p53. | Lapatinib | tumor protein p53 | Homo sapiens |
| 5 | Thus, our data suggest that mutant p53 sensitizes cancer cells to lapatinib via two complementary mechanisms: mutant p53 mediated amplification of ErbB2 signaling, and simultaneous annihilation of both potent oncogenic drivers, ErbB2 and mutant p53. | Lapatinib | tumor protein p53 | Homo sapiens |
| 6 | Thus, our data suggest that mutant p53 sensitizes cancer cells to lapatinib via two complementary mechanisms: mutant p53 mediated amplification of ErbB2 signaling, and simultaneous annihilation of both potent oncogenic drivers, ErbB2 and mutant p53. | Lapatinib | tumor protein p53 | Homo sapiens |