Title : Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome.

Pub. Date : 2016 Dec 1

PMID : 27789139






1 Functional Relationships(s)
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1 This could be accomplished through inhibition of enzymes in the cortisol synthetic pathway, 11beta-hydroxylase (Cyp11B1), 17alpha-hydroxylase-C17,20-lyase (Cyp17), and 21-hydroxylase (Cyp21). Hydrocortisone cytochrome P450 family 21 subfamily A member 2 Homo sapiens