Pub. Date : 2017 Jan
PMID : 27787886
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neuroglobin protects astroglial cells from hydrogen peroxide-induced oxidative stress and apoptotic cell death. | Hydrogen Peroxide | neuroglobin | Mus musculus |
| 2 | Thus, the purpose of this study was to investigate the potential glioprotective effect of Ngb on hydrogen peroxide (H2 O2 )-induced oxidative stress and apoptosis in cultured mouse astrocytes. | Hydrogen Peroxide | neuroglobin | Mus musculus |
| 3 | Thus, the purpose of this study was to investigate the potential glioprotective effect of Ngb on hydrogen peroxide (H2 O2 )-induced oxidative stress and apoptosis in cultured mouse astrocytes. | Hydrogen Peroxide | neuroglobin | Mus musculus |
| 4 | Incubation of cells with subnanomolar concentrations of Ngb (10-14 -10-10 M) was found to prevent both H2 O2 -evoked reduction in surviving cells number and accumulation of reactive oxygen species in a concentration-dependent manner. | Hydrogen Peroxide | neuroglobin | Mus musculus |
| 5 | Furthermore, Ngb treatment abolishes H2 O2 -induced increase in mitochondrial oxygen consumption rates. | Hydrogen Peroxide | neuroglobin | Mus musculus |
| 6 | Concomitantly, Ngb treatment rescues H2 O2 -associated reduced expression of endogenous antioxidant enzymes (superoxide dismutases and catalase) and prevents the stimulation of the expression of pro-inflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2, and interleukin (IL) IL-6 and IL-33). | Hydrogen Peroxide | neuroglobin | Mus musculus |
| 7 | Moreover, Ngb blocks the stimulation of Bax (pro-apoptotic) and the inhibition of Bcl-2 (anti-apoptotic) gene expression induced by H2 O2 , which in turn abolishes caspase 3 activation. | Hydrogen Peroxide | neuroglobin | Mus musculus |
| 8 | The protective effect of Ngb upon H2 O2 induced activation of caspase 3 activity and cell death can be accounted for by activation of protein kinase A and mitogen-activated protein kinase transduction cascade. | Hydrogen Peroxide | neuroglobin | Mus musculus |
| 9 | Finally, we demonstrate that Ngb increases Akt phosphorylation and prevents H2 O2 -provoked inhibition of ERK and Akt phosphorylation. | Hydrogen Peroxide | neuroglobin | Mus musculus |
| 10 | Taken together, these data demonstrate for the first time that Ngb is a glioprotective agent that prevents H2 O2 -induced oxidative stress and apoptotic astroglial cell death. | Hydrogen Peroxide | neuroglobin | Mus musculus |