Title : Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo.

Pub. Date : 2016 Oct 27

PMID : 27787519






1 Functional Relationships(s)
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1 In addition, metformin was shown to promote the expression of anabolic genes such as Col2a1 and Acan expression while inhibiting the expression of catabolic genes such as Mmp3 and Adamts5 in nucleus pulposus cells. Metformin aggrecan Rattus norvegicus