Pub. Date : 2017
PMID : 27779078
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, it is becoming increasingly clear that prolonged exposure of beta-cells to hyperglycemic conditions, leads to sustained activation of Rac1-Nox2 signaling axis culminating in excessive generation of intracellular ROS (oxidative stress) and beta-cell dysregulation and demise. | Reactive Oxygen Species | Rac family small GTPase 1 | Homo sapiens |
| 2 | We have provided an overview of existing evidence in the islet beta-cell on the regulatory roles of these MAPKs in mediating cellular responses to alterations in intracellularly generated ROS, which is mediated by the Rac1-Nox2 signaling module. | Reactive Oxygen Species | Rac family small GTPase 1 | Homo sapiens |