Title : Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-κB and P2X7R Signaling in PMA-Induced Macrophages.

Pub. Date : 2016

PMID : 27777559






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Results: Curcumin significantly reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion in PMA-induced macrophages. Tetradecanoylphorbol Acetate interleukin 1 beta Homo sapiens
2 Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion. Tetradecanoylphorbol Acetate interleukin 1 beta Homo sapiens