Pub. Date : 2016
PMID : 27777559
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-kappaB and P2X7R Signaling in PMA-Induced Macrophages. | Curcumin | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | This study aimed to assess the effects of curcumin on NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages and explore its underlying mechanism. | Curcumin | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Results: Curcumin significantly reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion in PMA-induced macrophages. | Curcumin | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion. | Curcumin | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | Conclusion: Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA-induced macrophages. | Curcumin | NLR family pyrin domain containing 3 | Homo sapiens |