Title : Metformin alters DNA methylation genome-wide via the H19/SAHH axis.

Pub. Date : 2017 Apr 27

PMID : 27775072






3 Functional Relationships(s)
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1 Metformin acts by upregulating microRNA let-7 through AMPK activation, leading to degradation of H19 long noncoding RNA, which normally binds to and inactivates SAHH. Metformin H19 imprinted maternally expressed transcript Homo sapiens
2 This metformin-induced H19 repression and alteration of gene methylation are recapitulated in endometrial cancer tissue samples obtained from patients treated with antidiabetic doses of metformin. Metformin H19 imprinted maternally expressed transcript Homo sapiens
3 This metformin-induced H19 repression and alteration of gene methylation are recapitulated in endometrial cancer tissue samples obtained from patients treated with antidiabetic doses of metformin. Metformin H19 imprinted maternally expressed transcript Homo sapiens