Pub. Date : 2016 Dec
PMID : 27771463
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide-induced destabilization of SIRT1 by inactivating JNK. | Rosiglitazone | sirtuin 1 | Mus musculus |
| 2 | Activation of PPARgamma by rosiglitazone, a specific ligand of PPARgamma, rescues LPS-induced destabilization of SIRT1, with a concomitant decrease in phosphorylation of residue Ser-46, which is targeted by JNK-1 to promote proteasome-mediated degradation of SIRT1. | Rosiglitazone | sirtuin 1 | Mus musculus |
| 3 | Activation of PPARgamma by rosiglitazone, a specific ligand of PPARgamma, rescues LPS-induced destabilization of SIRT1, with a concomitant decrease in phosphorylation of residue Ser-46, which is targeted by JNK-1 to promote proteasome-mediated degradation of SIRT1. | Rosiglitazone | sirtuin 1 | Mus musculus |
| 4 | The rosiglitazone-mediated increase in SIRT1 stability is accompanied by upregulation of mitogen-activated protein kinase phosphatase (MKP)-7, a JNK-specific phosphatase. | Rosiglitazone | sirtuin 1 | Mus musculus |
| 5 | Furthermore, gain of MKP-7 function mimicked the effect of rosiglitazone on LPS-induced destabilization and ubiquitination of SIRT1. | Rosiglitazone | sirtuin 1 | Mus musculus |