Title : An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924).

Pub. Date : 2016 Nov 18

PMID : 27771247






1 Functional Relationships(s)
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1 In the present mechanistic analyses, pevonedistat induced TNFalpha mRNA and triggered IAP antagonist-dependent extrinsic apoptotic cell death in cancer cell lines. pevonedistat tumor necrosis factor Homo sapiens