Title : Neovascularization and functional recovery after intracerebral hemorrhage is conditioned by the Tp53 Arg72Pro single-nucleotide polymorphism.

Pub. Date : 2017 Jan

PMID : 27768124






3 Functional Relationships(s)
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Protein Name
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1 The human Tp53 gene harbors a common single-nucleotide polymorphism (SNP) at codon 72, which yields an arginine-to-proline amino-acidic substitution (Arg72Pro) that modulates the apoptotic activity of the p53 protein. Arginine tumor protein p53 Homo sapiens
2 The human Tp53 gene harbors a common single-nucleotide polymorphism (SNP) at codon 72, which yields an arginine-to-proline amino-acidic substitution (Arg72Pro) that modulates the apoptotic activity of the p53 protein. Arginine tumor protein p53 Homo sapiens
3 Patients harboring the Pro allele of the Tp53 Arg72Pro SNP showed higher levels of circulating EPC-containing CD34+ cells, EPC-mobilizing cytokines - vascular endothelial growth factor and stromal cell-derived factor-1alpha - and good functional outcome following ICH, when compared with the homozygous Arg allele patients, which is compatible with increased neovascularization. Arginine tumor protein p53 Homo sapiens