Title : Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation.

Pub. Date : 2016 Dec 13

PMID : 27765932






2 Functional Relationships(s)
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1 Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1alpha, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation. Cisplatin MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 We report here that cisplatin supppresses ASS1 expression is due to upregulation of HIF-1alpha and downregulation of c-Myc, which function as negative and positive regulators of ASS1 expression, respectively, by reciprocal bindings to the ASS1 promoter. Cisplatin MYC proto-oncogene, bHLH transcription factor Homo sapiens