Pub. Date : 2016 Dec 13
PMID : 27765932
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1alpha, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
2 | We report here that cisplatin supppresses ASS1 expression is due to upregulation of HIF-1alpha and downregulation of c-Myc, which function as negative and positive regulators of ASS1 expression, respectively, by reciprocal bindings to the ASS1 promoter. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |