Pub. Date : 2017 Mar
PMID : 27757735
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1. | Amsacrine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Further, amsacrine-treated U937 cells showed AKT degradation and Ca2+-mediated ERK inactivation. | Amsacrine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Restoration of ERK phosphorylation and AKT expression abrogated amsacrine-induced MCL1 down-regulation. | Amsacrine | AKT serine/threonine kinase 1 | Homo sapiens |