Title : Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.

Pub. Date : 2017 Jan

PMID : 27754931






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Autotaxin (ATX) is a secreted glycoprotein that converts lysophosphatidylcholine (LPC) to the bioactive phospholipid lysophosphatidic acid (LPA) and is the major enzyme generating circulating LPA. lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus
2 Autotaxin (ATX) is a secreted glycoprotein that converts lysophosphatidylcholine (LPC) to the bioactive phospholipid lysophosphatidic acid (LPA) and is the major enzyme generating circulating LPA. lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus
3 Autotaxin (ATX) is a secreted glycoprotein that converts lysophosphatidylcholine (LPC) to the bioactive phospholipid lysophosphatidic acid (LPA) and is the major enzyme generating circulating LPA. lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus
4 Autotaxin (ATX) is a secreted glycoprotein that converts lysophosphatidylcholine (LPC) to the bioactive phospholipid lysophosphatidic acid (LPA) and is the major enzyme generating circulating LPA. lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus
5 However, other LPA-generating pathways exist, and the role of ATX in localized tissue LPA production and fibrosis remains unclear and controversial. lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus