Title : Dynamics of Adrenocorticotropin after Application of Metyrapone.

Pub. Date : 2017 Jan

PMID : 27750352






6 Functional Relationships(s)
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1 Dynamics of Adrenocorticotropin after Application of Metyrapone. Metyrapone proopiomelanocortin Homo sapiens
2 Purpose: To investigate the kinetics of adrenocorticotropin (ACTH) following oral metyrapone administration and describe differences between ACTH-deficient and non-ACTH-deficient subjects. Metyrapone proopiomelanocortin Homo sapiens
3 Purpose: To investigate the kinetics of adrenocorticotropin (ACTH) following oral metyrapone administration and describe differences between ACTH-deficient and non-ACTH-deficient subjects. Metyrapone proopiomelanocortin Homo sapiens
4 Results: A significant rise in ACTH concentration compared to basal values was found at 60 and 120 min following oral metyrapone administration. Metyrapone proopiomelanocortin Homo sapiens
5 Conclusion: In contrast to previous reports, we found a significant rise in ACTH concentration as soon as one hour after oral metyrapone administration. Metyrapone proopiomelanocortin Homo sapiens
6 Further studies are needed to investigate this finding as a potential basis for a ACTH-based metyrapone short test protocol. Metyrapone proopiomelanocortin Homo sapiens