Title : ORP4L Facilitates Macrophage Survival via G-Protein-Coupled Signaling: ORP4L-/- Mice Display a Reduction of Atherosclerosis.

Pub. Date : 2016 Dec 9

PMID : 27729467






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Excessive stimulation with the oxysterol 25-hydroxycholesterol disassembles the ORP4L/Galphaq/11/PLCbeta3 complexes, resulting in reduced PLCbeta3 activity, IP3 production, and Ca2+ release, as well as decreased Bcl-XL expression and increased apoptosis. 25-hydroxycholesterol guanine nucleotide binding protein, alpha q polypeptide Mus musculus