Pub. Date : 2016 Oct 7
PMID : 27713569
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A single dose of TCDD administered to adult mice induced Ahr-dependent CpG hypomethylation, changes in histone modifications, and thymine DNA glycosylase (Tdg) recruitment at the Cyp1a1 promoter in the liver within 24 hrs. | Polychlorinated Dibenzodioxins | thymine DNA glycosylase | Mus musculus |
| 2 | A single dose of TCDD administered to adult mice induced Ahr-dependent CpG hypomethylation, changes in histone modifications, and thymine DNA glycosylase (Tdg) recruitment at the Cyp1a1 promoter in the liver within 24 hrs. | Polychlorinated Dibenzodioxins | thymine DNA glycosylase | Mus musculus |
| 3 | Our demethylation assay using siRNA knockdown and an in vitro methylated plasmid showed that Ahr, Tdg, and the ten-eleven translocation methyldioxygenases Tet2 and Tet3 are required for the TCDD-induced DNA demethylation. | Polychlorinated Dibenzodioxins | thymine DNA glycosylase | Mus musculus |