Title : Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition.

Pub. Date : 2016 Nov 22

PMID : 27708213






3 Functional Relationships(s)
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1 Our genomic analyses reveal high correlation between response to talazoparib and Schlafen 11 (SLFN11) expression. talazoparib schlafen family member 11 Homo sapiens
2 Our genomic analyses reveal high correlation between response to talazoparib and Schlafen 11 (SLFN11) expression. talazoparib schlafen family member 11 Homo sapiens
3 Response to the talazoparib-temozolomide combination was also driven by SLFN11 and validated in 36 small cell lung cancer cell lines, and in xenograft models. talazoparib schlafen family member 11 Homo sapiens