Pub. Date : 2017 Mar
PMID : 27707884
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ikaros 6 protects acute lymphoblastic leukemia cells against daunorubicin-induced apoptosis by activating the Akt-FoxO1 pathway. | Daunorubicin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Upon treatment with daunorubicin, Nalm-6/Ik6 cells exhibited a statistically significant reduction in apoptosis, with increased expression of p-Akt and p-FoxO1. | Daunorubicin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In conclusion, Ik6, the upstream factor of Akt-FoxO1 pathway, can protect ALL cells against daunorubicin-induced apoptosis and can potentially be explored as a therapeutic target in the treatment of patients with ALL. | Daunorubicin | AKT serine/threonine kinase 1 | Homo sapiens |