Title : Ascorbic acid within chromaffin granules. In situ kinetics of norepinephrine biosynthesis.

Pub. Date : 1989 Sep 15

PMID : 2768269






4 Functional Relationships(s)
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1 These data indicate that intragranular ascorbic acid is available and required for norepinephrine biosynthesis, that ascorbic acid is a true co-substrate for dopamine beta-monooxygenase, and that intragranular ascorbic acid is maintained by extragranular ascorbic acid. Ascorbic Acid dopamine beta-hydroxylase Bos taurus
2 These data indicate that intragranular ascorbic acid is available and required for norepinephrine biosynthesis, that ascorbic acid is a true co-substrate for dopamine beta-monooxygenase, and that intragranular ascorbic acid is maintained by extragranular ascorbic acid. Ascorbic Acid dopamine beta-hydroxylase Bos taurus
3 These data indicate that intragranular ascorbic acid is available and required for norepinephrine biosynthesis, that ascorbic acid is a true co-substrate for dopamine beta-monooxygenase, and that intragranular ascorbic acid is maintained by extragranular ascorbic acid. Ascorbic Acid dopamine beta-hydroxylase Bos taurus
4 Furthermore, in situ kinetics of dopamine beta-monooxygenase for ascorbic acid may be most accurately determined using intact granules and the true physiologic substrate. Ascorbic Acid dopamine beta-hydroxylase Bos taurus