Title : Immunomodulatory effects of nicotine on interleukin 1β activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism.

Pub. Date : 2016 Sep 29

PMID : 27681882






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1 Immunomodulatory effects of nicotine on interleukin 1beta activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism. Nicotine interleukin 1 beta Homo sapiens
2 Here, we investigated the effects of nicotine, an ACh receptor agonist, on the cytokine and cholinesterase production of immunocompetent human astrocytes stimulated with interleukin 1beta (IL-1beta) in vitro. Nicotine interleukin 1 beta Homo sapiens
3 Here, we investigated the effects of nicotine, an ACh receptor agonist, on the cytokine and cholinesterase production of immunocompetent human astrocytes stimulated with interleukin 1beta (IL-1beta) in vitro. Nicotine interleukin 1 beta Homo sapiens
4 RESULTS: Nicotine treatment dose dependently limits the production of critical proinflammatory cytokines such as IL-6 (60.5 +- 3.3, %inhibition), IL-1beta (42.4 +- 1.7, %inhibition), and TNF-alpha (68.9 +- 7.7, %inhibition) by activated human astrocytes. Nicotine interleukin 1 beta Homo sapiens