Pub. Date : 2016 Dec
PMID : 27677871
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Z-Guggulsterone Improves the Scopolamine-Induced Memory Impairments Through Enhancement of the BDNF Signal in C57BL/6J Mice. | pregna-4,17-diene-3,16-dione | brain derived neurotrophic factor | Mus musculus |
| 2 | Mechanistic studies revealed that Z-guggulsterone pretreatment reversed the scopolamine-induced increase in acetylcholinesterase (AchE) activity, as well as decreases in brain-derived neurotrophic factor (BDNF) protein expression and cAMP response element-binding protein (CREB), extracellular regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) phosphorylation levels in the hippocampus and cortex. | pregna-4,17-diene-3,16-dione | brain derived neurotrophic factor | Mus musculus |
| 3 | Mechanistic studies revealed that Z-guggulsterone pretreatment reversed the scopolamine-induced increase in acetylcholinesterase (AchE) activity, as well as decreases in brain-derived neurotrophic factor (BDNF) protein expression and cAMP response element-binding protein (CREB), extracellular regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) phosphorylation levels in the hippocampus and cortex. | pregna-4,17-diene-3,16-dione | brain derived neurotrophic factor | Mus musculus |
| 4 | Inhibition of the BDNF signal, however, blocked the memory-enhancing effect of Z-guggulsterone. | pregna-4,17-diene-3,16-dione | brain derived neurotrophic factor | Mus musculus |
| 5 | Therefore, these findings demonstrate that Z-guggulsterone attenuates the scopolamine-induced memory impairments mainly through activation of the CREB-BDNF signaling pathway, thereby exhibiting memory-improving effects. | pregna-4,17-diene-3,16-dione | brain derived neurotrophic factor | Mus musculus |