Pub. Date : 2016 Nov 1
PMID : 27673371
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reversible Covalent Binding to Cardiac Troponin C by the Ca2+-Sensitizer Levosimendan. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 2 | While the primary target of levosimendan is thought to be cTnC, the molecular details of this interaction are not well understood. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 3 | In this study, we used mass spectrometry, computational chemistry, and nuclear magnetic resonance spectroscopy to demonstrate that levosimendan reacts specifically with cysteine 84 of cTnC to form a reversible thioimidate bond. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 4 | We also showed that levosimendan only reacts with the active, Ca2+-bound conformation of cTnC. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 5 | Finally, we propose a structural model of levosimendan bound to cTnC, which suggests that the Ca2+-sensitizing function of levosimendan is due to stabilization of the Ca2+-bound conformation of cTnC. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 6 | Finally, we propose a structural model of levosimendan bound to cTnC, which suggests that the Ca2+-sensitizing function of levosimendan is due to stabilization of the Ca2+-bound conformation of cTnC. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 7 | Finally, we propose a structural model of levosimendan bound to cTnC, which suggests that the Ca2+-sensitizing function of levosimendan is due to stabilization of the Ca2+-bound conformation of cTnC. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |
| 8 | Finally, we propose a structural model of levosimendan bound to cTnC, which suggests that the Ca2+-sensitizing function of levosimendan is due to stabilization of the Ca2+-bound conformation of cTnC. | Simendan | troponin C1, slow skeletal and cardiac type | Homo sapiens |