Pub. Date : 2016 Nov 15
PMID : 27671678
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using synthetic lethality approaches, we identified molecular pathways whose inhibition sensitizes HER2+ breast cancer cells to lapatinib both in vitro and in vivo, including JAK2/STAT3 and hyaluronic acid. | Lapatinib | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | Neoadjuvant lapatinib therapy in HER2+ breast tumors lead to a significant increase of phospho-STAT3+ cancer cells and a decrease in the spatial proximity of proliferating (Ki67+) cells to CAFs impacting therapeutic responses. | Lapatinib | signal transducer and activator of transcription 3 | Homo sapiens |