Title : HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix.

Pub. Date : 2016 Sep 27

PMID : 27671118






9 Functional Relationships(s)
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1 We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation. Chondroitin Sulfates pleiotrophin Homo sapiens
2 We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation. Chondroitin Sulfates pleiotrophin Homo sapiens
3 We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation. Chondroitin Sulfates pleiotrophin Homo sapiens
4 We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation. Chondroitin Sulfates pleiotrophin Homo sapiens
5 We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation. Chondroitin Sulfates pleiotrophin Homo sapiens
6 We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation. Chondroitin Sulfates pleiotrophin Homo sapiens
7 The CS-bound HB-GAM promotes neurite growth through binding to the cell surface proteoglycan glypican-2; furthermore, HB-GAM abrogates the CS ligand binding to the inhibitory receptor PTPsigma (protein tyrosine phosphatase sigma). Chondroitin Sulfates pleiotrophin Homo sapiens
8 The CS-bound HB-GAM promotes neurite growth through binding to the cell surface proteoglycan glypican-2; furthermore, HB-GAM abrogates the CS ligand binding to the inhibitory receptor PTPsigma (protein tyrosine phosphatase sigma). Chondroitin Sulfates pleiotrophin Homo sapiens
9 The CS-bound HB-GAM promotes neurite growth through binding to the cell surface proteoglycan glypican-2; furthermore, HB-GAM abrogates the CS ligand binding to the inhibitory receptor PTPsigma (protein tyrosine phosphatase sigma). Chondroitin Sulfates pleiotrophin Homo sapiens