Title : Donepezil promotes differentiation of neural stem cells into mature oligodendrocytes at the expense of astrogenesis.

Pub. Date : 2017 Jan

PMID : 27664791






1 Functional Relationships(s)
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1 Moreover, donepezil increased oligodendrocyte differentiation, resulting in a reduction in the differentiation of NSCs into astrocytes, by suppressing the activation of signal transducer and activator of transcription 3 (STAT3), SMAD1/5/9, and the downstream target gene GFAP, even under astrocyte-inducing conditions. Donepezil SMAD family member 1 Homo sapiens