Title : IL-1β maintains the redox balance by regulating glutaredoxin 1 expression during oral carcinogenesis.

Pub. Date : 2017 May

PMID : 27658048






5 Functional Relationships(s)
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1 The ROS levels were detected in Leti-si-IL-1beta and Leti-si-NC CAL27 cells after IL-1beta stimulation. Reactive Oxygen Species interleukin 1 beta Homo sapiens
2 The ROS levels were detected in Leti-si-IL-1beta and Leti-si-NC CAL27 cells after IL-1beta stimulation. Reactive Oxygen Species interleukin 1 beta Homo sapiens
3 Exogenous IL-1beta upregulated the intracellular ROS level and the expression of Grx1 in CAL27 cells, which could be counteracted by IL-1Ra. Reactive Oxygen Species interleukin 1 beta Homo sapiens
4 The intracellular ROS accumulation induced by exogenous IL-1beta was responsible for the Grx1 upregulation. Reactive Oxygen Species interleukin 1 beta Homo sapiens
5 Endogenous IL-1beta acted as a switch in regulating the ROS level by modulating Grx1 expression, which was involved in the invasion and migration of OSCC cells. Reactive Oxygen Species interleukin 1 beta Homo sapiens