Title : Isolated Polar Amino Acid Residues Modulate Lipid Binding in the Large Hydrophobic Cavity of CD1d.

Pub. Date : 2016 Nov 18

PMID : 27648599






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 A series of the ligands, alpha-galactosyl ceramide (alpha-GalCer) derivatives containing polar groups in the acyl chain, was synthesized, and the structure-activity relationship studies demonstrated that simple modification from a methylene to an amide group in the long fatty acyl chain, when introduced at optimal positions, enhanced the CD1d recognition of the glycolipid ligands. Amides CD1d molecule Homo sapiens