Pub. Date : 1989
PMID : 2764709
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A hepatic soluble aldehyde dehydrogenase (ALDH), inducible by polycyclic aromatic hydrocarbons, was studied in Wistar rats in connection with substances known to affect drug metabolism or aldehyde dehydrogenase activity, such as phenobarbital (PB), disulfiram (DS), beta-diethylaminoethyl diphenylpropylacetate (SKF 525A) and calcium cyanamide (CC). | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 2 | A hepatic soluble aldehyde dehydrogenase (ALDH), inducible by polycyclic aromatic hydrocarbons, was studied in Wistar rats in connection with substances known to affect drug metabolism or aldehyde dehydrogenase activity, such as phenobarbital (PB), disulfiram (DS), beta-diethylaminoethyl diphenylpropylacetate (SKF 525A) and calcium cyanamide (CC). | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 3 | A hepatic soluble aldehyde dehydrogenase (ALDH), inducible by polycyclic aromatic hydrocarbons, was studied in Wistar rats in connection with substances known to affect drug metabolism or aldehyde dehydrogenase activity, such as phenobarbital (PB), disulfiram (DS), beta-diethylaminoethyl diphenylpropylacetate (SKF 525A) and calcium cyanamide (CC). | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 4 | A hepatic soluble aldehyde dehydrogenase (ALDH), inducible by polycyclic aromatic hydrocarbons, was studied in Wistar rats in connection with substances known to affect drug metabolism or aldehyde dehydrogenase activity, such as phenobarbital (PB), disulfiram (DS), beta-diethylaminoethyl diphenylpropylacetate (SKF 525A) and calcium cyanamide (CC). | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 5 | On the contrary, pretreatment with DS (100 mg/kg, i.p., daily x 4) reduced by 70% the expected increase in ALDH activity. | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |
| 6 | At the above doses, basal ALDH activity was inhibited by DS (30%) and CC (70%), but was not affected at all by PB or SKF 525A. | Disulfiram | aldehyde dehydrogenase 3 family, member A1 | Rattus norvegicus |