Title : Heterozygous mutation of cysteine528 in XPO1 is sufficient for resistance to selective inhibitors of nuclear export.

Pub. Date : 2016 Oct 18

PMID : 27634897






1 Functional Relationships(s)
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1 However, introduction of a homozygous mutation at the drug"s target site, the cysteine 528 residue inside the XPO1 cargo-binding pocket, by genetic engineering, confers resistance to selinexor. Cysteine exportin 1 Homo sapiens