Pub. Date : 2016 Nov
PMID : 27633099
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lapatinib-resistant cancer cells possessing epithelial cancer stem cell properties develop sensitivity during sphere formation by activation of the ErbB/AKT/cyclin D2 pathway. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Furthermore, the phosphorylation levels of ErbB2, ErbB3 and Akt and the protein levels of cyclin D1 were decreased by lapatinib treatment of HSC3, HSC4 and Ca9-22 cells. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | The phosphorylation levels of ErbB2 and AKT and protein levels of cyclin D2 increased during sphere formation of SAS cells and decreased with lapatinib treatment. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | These results suggested that phosphorylation of EGFR and ErbB2 by cell detachment from the substratum induces the AKT pathway/cyclin D2-dependent sphere growth in SAS epithelial cancer stem-like cells, thereby rendering SAS spheres sensitive to lapatinib treatment. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |