Title : Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy.

Pub. Date : 2016 Nov 15

PMID : 27626315






1 Functional Relationships(s)
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1 As pro-inflammatory mediators are reported modulators of the autophagy processes, treatment with the pro-inflammatory cytokine TNFalpha resulted in 1) increased Fyn activity 2) stimulated Fyn-dependent AMPKalpha tyrosine phosphorylation and 3) decreased AICAR-dependent AMPK activation. Tyrosine FYN proto-oncogene, Src family tyrosine kinase Homo sapiens