Title : GSK-3β-mediated fatty acid synthesis enhances epithelial to mesenchymal transition of TLR4-activated colorectal cancer cells through regulation of TAp63.

Pub. Date : 2016 Nov

PMID : 27599658






3 Functional Relationships(s)
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1 GSK-3beta-mediated fatty acid synthesis enhances epithelial to mesenchymal transition of TLR4-activated colorectal cancer cells through regulation of TAp63. Fatty Acids toll like receptor 4 Homo sapiens
2 We investigated the role of GSK-3beta-mediated intracellular fatty acid synthesis to control EMT in TLR4-activated colorectal cancer cells and the underlying regulatory mechanism. Fatty Acids toll like receptor 4 Homo sapiens
3 These results suggest that TAp63-mediated GSK-3beta activation induced by TLR4 stimulation triggers migration and invasion of colon cancer cells through the regulation of lipid synthesis and GSK-3beta-mediated CD74/CD44 expression could be a target to control fatty acid-related EMT process through the modulation of TAp63 expression. Fatty Acids toll like receptor 4 Homo sapiens