Pub. Date : 2017 Jun 1
PMID : 27592100
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein. | Acrolein | transient receptor potential cation channel, subfamily A, member 1 | Mus musculus |
| 2 | Because the transient receptor potential ankyrin 1 (TRPA1) channel mediates tobacco smoke-induced lung injury, we assessed its role in high-level acrolein-induced toxicity in mice. | Acrolein | transient receptor potential cation channel, subfamily A, member 1 | Mus musculus |
| 3 | Both male and female TRPA1-null mice were more sensitive to acrolein-induced mortality than age- and sex-matched WT mice. | Acrolein | transient receptor potential cation channel, subfamily A, member 1 | Mus musculus |
| 4 | Acrolein exposure increased lung weight:body weight ratios and lung albumin and decreased plasma albumin to a greater extent in TRPA1-null than in WT mice. | Acrolein | transient receptor potential cation channel, subfamily A, member 1 | Mus musculus |
| 5 | These data show TRPA1 protects against high-level acrolein-induced toxicity in a sex-dependent manner. | Acrolein | transient receptor potential cation channel, subfamily A, member 1 | Mus musculus |
| 6 | Post-exposure TRPA1 antagonism also protected against acrolein-induced mortality attesting to a complex role of TRPA1 in cardiopulmonary injury. | Acrolein | transient receptor potential cation channel, subfamily A, member 1 | Mus musculus |
| 7 | Post-exposure TRPA1 antagonism also protected against acrolein-induced mortality attesting to a complex role of TRPA1 in cardiopulmonary injury. | Acrolein | transient receptor potential cation channel, subfamily A, member 1 | Mus musculus |