Title : Disulfiram and Diphenhydramine Hydrochloride Upregulate miR-30a to Suppress IL-17-Associated Autoimmune Inflammation.

Pub. Date : 2016 Aug 31

PMID : 27581464






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Disulfiram and Diphenhydramine Hydrochloride Upregulate miR-30a to Suppress IL-17-Associated Autoimmune Inflammation. Disulfiram microRNA 30a Mus musculus
2 Through screening of 640 different Food and Drug Administration (FDA)-approved drugs, we found that disulfiram and diphenhydramine hydrochloride were effective candidates for inhibiting Th17 differentiation and ameliorating EAE development through upregulating miR-30a. Disulfiram microRNA 30a Mus musculus
3 Interestingly, by performing a chemical screen with Food and Drug Administration-approved small-molecule drugs, we found that disulfiram and diphenhydramine upregulated miR-30a and suppressed Th17-associated autoimmune demyelination. Disulfiram microRNA 30a Mus musculus