Title : Resveratrol Ameliorates Dysregulation of Th1, Th2, Th17, and T Regulatory Cell-Related Transcription Factor Signaling in a BTBR T + tf/J Mouse Model of Autism.

Pub. Date : 2017 Sep

PMID : 27578011






3 Functional Relationships(s)
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1 Resveratrol (20 and 40 mg/kg) treatment to B6 and BTBR mice showed substantial induction of Foxp3+ and reduction of T-bet+, GATA-3+, and IL-17A+ expression in CD4+ cells when compared with the respective control groups. Resveratrol GATA binding protein 3 Mus musculus
2 Moreover, resveratrol treatment resulted in upregulated expression of Foxp3 mRNA and decreased expression levels of T-bet, GATA-3, RORgammat, and IL-17A in the spleen and brain tissues. Resveratrol GATA binding protein 3 Mus musculus
3 Western blot analysis confirmed that resveratrol treatment decreased the protein expression of T-bet, GATA-3, RORgamma, and IL-17 and that it increased Foxp3 in B6 and BTBR mice. Resveratrol GATA binding protein 3 Mus musculus