Title : Aminopyridinyl-Pseudodeoxycytidine Derivatives Selectively Stabilize Antiparallel Triplex DNA with Multiple CG Inversion Sites.

Pub. Date : 2016 Sep 26

PMID : 27576703






1 Functional Relationships(s)
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1 Remarkably, 3-methyl-2-aminopyridinyl-PsidC ((Me) AP-PsidC) formed a stable triplex with the promoter sequence of the hTERT gene containing four CG inversion sites, and effectively inhibited its transcription in human cancer cells. 3-methyl-2-aminopyridinyl-psidc telomerase reverse transcriptase Homo sapiens