Title : Alcohol and Aldehyde Dehydrogenases Contribute to Sex-Related Differences in Clearance of Zolpidem in Rats.

Pub. Date : 2016

PMID : 27574509






1 Functional Relationships(s)
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1 Administration of disulfiram caused more drastic C MAX and T MAX changes in male vs. female rats that mirrored the effects of castration on first-pass metabolism, suggesting that the observed PK differences may be caused by ADH/ALDH expression. Disulfiram aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus