Pub. Date : 2016 Jul
PMID : 27563417
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We examined changes in gene expression of the NMDA receptor subunit 1 (NR1) at mRNA levels in rat striatum and prefrontal cortex (PFC) after induction of morphine tolerance. | Morphine | glutamate ionotropic receptor NMDA type subunit 1 | Rattus norvegicus |
| 2 | The results also showed that the NR1 gene expression at mRNA level in rats tolerant to morphine was significantly increased in the striatum (P<0.01) but decreased in the PFC (P<0.001). | Morphine | glutamate ionotropic receptor NMDA type subunit 1 | Rattus norvegicus |
| 3 | CONCLUSION: Therefore, changes in the NR1 gene expression in rat striatum and PFC have a region-specific association with morphine-induced analgesic tolerance. | Morphine | glutamate ionotropic receptor NMDA type subunit 1 | Rattus norvegicus |