Title : Dihydrotestosterone synthesis pathways from inactive androgen 5α-androstane-3β,17β-diol in prostate cancer cells: Inhibition of intratumoural 3β-hydroxysteroid dehydrogenase activities by abiraterone.

Pub. Date : 2016 Aug 26

PMID : 27561382






4 Functional Relationships(s)
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1 Abiraterone had a significant influence on the metabolism of DHEA, epiandrosterone and 3beta-diol, by the inhibition of the intratumoural 3beta-hydroxysteroid dehydrogenase (3beta-HSD) activities which is one of key catalysts in androgen metabolic pathway. Androstane-3,17-diol hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens
2 Abiraterone had a significant influence on the metabolism of DHEA, epiandrosterone and 3beta-diol, by the inhibition of the intratumoural 3beta-hydroxysteroid dehydrogenase (3beta-HSD) activities which is one of key catalysts in androgen metabolic pathway. Androstane-3,17-diol hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens
3 The direct-conversion of 3beta-diol to DHT was catalysed by 3beta-HSD and abiraterone could inhibit this activity of 3beta-HSD. Androstane-3,17-diol hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens
4 The direct-conversion of 3beta-diol to DHT was catalysed by 3beta-HSD and abiraterone could inhibit this activity of 3beta-HSD. Androstane-3,17-diol hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens