Title : Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis.

Pub. Date : 2016

PMID : 27518439






1 Functional Relationships(s)
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1 CONCLUSIONS: Mice with CSE (an H2S synthesising enzyme) gene deletion are less susceptible to CLP-induced sepsis and associated inflammatory response through ERK1/2-NF-kappaB p65 pathway as evidenced by reduced inflammation, tissue damage, and LSECs defenestration and gaps formation. Hydrogen Sulfide mitogen-activated protein kinase 3 Mus musculus