Title : Design and synthesis of cis-restricted benzimidazole and benzothiazole mimics of combretastatin A-4 as antimitotic agents with apoptosis inducing ability.

Pub. Date : 2016 Sep 15

PMID : 27515320






1 Functional Relationships(s)
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1 A series of colchicine site binding tubulin inhibitors were designed and synthesized by the modification of the combretastatin A-4 (CA4) pharmacophore. Colchicine carbonic anhydrase 4 Homo sapiens