Title : 4-Biphenylalanine- and 3-Phenyltyrosine-Derived Hydroxamic Acids as Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

Pub. Date : 2016 Sep 20

PMID : 27505861






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 With extensive chemical modifications on the lead structure, also by exploiting the versatility of the radical arylation with aryldiazonium salts, we were able to increase the potency of the derivatives against KDM4A to the low-micromolar range and, more importantly, to obtain demethylase selectivity with respect to HDACs. aryldiazonium salts lysine demethylase 4A Homo sapiens