Pub. Date : 2016 Aug
PMID : 27502370
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin E2 Reduces Cardiac Contractility via EP3 Receptor. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 2 | BACKGROUND: Prostaglandin E2 (PGE2) EP receptors EP3 and EP4 signal via decreased and increased cAMP production, respectively. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 3 | BACKGROUND: Prostaglandin E2 (PGE2) EP receptors EP3 and EP4 signal via decreased and increased cAMP production, respectively. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 4 | Thus, we hypothesized that PGE2 increases contractility via EP4 but decreases contractility via EP3. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 5 | Both PGE2 and sulprostone decreased +dp/dt (P<0.01) and left ventricular developed pressure (P<0.001) with reversal by an EP3 antagonist. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |